ABSTRACT
The study was carried out in the Department of Physiology, Isra University, Hyderabad. Seventy three cases of viperidae snake bite were studied to observe the pattern of coagulopathy. All had prolonged clotting time at the time of admission. Prothrombin time was increased in 56 cases, activated partial thromboplastin time was increased in 63 cases, bleeding time was normal in all cases. Platelet count was decreased in 28 cases and fibrinogen levels were decreased in 36 cases. Disseminated intravascular coagulation was found to be the predominant pattern of coagulopathy in viperidae snake bite cases
Subject(s)
Humans , Male , Female , Snake Venoms/blood , Snake Venoms/adverse effects , Blood Coagulation Disorders/blood , Blood Coagulation Disorders/chemically induced , Blood Coagulation Disorders/diagnosis , Blood Coagulation Disorders/mortality , Blood Coagulation Disorders/pathology , Disseminated Intravascular Coagulation , Blood Coagulation TestsABSTRACT
This study included 10 cases of viperidae snake bite that developed acute renal failure out of 73 cases admitted to various wards of Liaquat Medical College hospital during the last two years. All these patients reported to the hospital 3-5 days after the bite. All had signs of severe envenomation with incoagulable blood and prolonged PT and APTT. All has bleeding manifestations. Blood urea and serum creatinine were increased in all patients and four were anuric. Leucocytosis and thrombocytopenia were found in 7 cases, serum bilirubin was increased in 4 cases, 4 patients required dialysis and 4 out of 10 cases expired. Bad prognostic features included severe envenomation, leucocytosis, thrombocytopenia, and necessity for dialysis. We conclude that acute renal failure is a serious complication of viperidae snake bite with high mortality rate and it necessitates early and effective treatment